MAGNESIUM OROTATE

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Magnesium Orotate (MgOr) is more effective than other magnesium supplements. It penetrates cell membranes and delivers the magnesium ion inside the cell at the level of the mitochondria and the cell nucleus.

As we shall see, MgOr has documented benefits in treating and improving outcomes of cardiovascular disorders such as heart attacks, arrhythmias, blood vessel stiffness, atherosclerosis, pacemaker function and high blood pressure. It is also used by competitive athletes to increase endurance, and treat symptoms of other magnesium deficiencies, including diabetes, dementia, and osteoporosis, as well as to treat migraines, asthma, chronic lung disease and various types of cancer. If you are worried or suffering from any of these conditions I suggest you take the no-obligation Inflammation Survey

Heart and Blood Vessel Diseases are one of the Leading Causes of Death
Their prevention and therapy are very important. It is important to understand that free radicals are highly toxic to heart cells and are involved in ischemia/reperfusion injury.

Deficient cellular nutrition created by metabolic abnormalities is an important consideration in the pathogenesis of both skeletal and cardiac muscle dysfunction. (Sole, Mj 2003) Several specific deficiencies have been found in the failing myocardium:

• The important myocardial energy producers L-carnitine, coenzyme Q10, creatine, thiamine and magnesium are reduced
• A relative deficiency of taurine, an amino acid that is integral to the modulation of intracellular calcium levels often coexists with an increase in myocardial oxidative stress (see more on Taurine below)
• A reduction of both endogenous and exogenous antioxidant defenses is present.
• In addition, these processes may negatively impact skeletal muscle metabolism and function.

The good new is that each of these deficiencies is amenable to restoration through dietary supplementation. For example

• Magnesium Orotate reduces serum cholesterol levels.
• It prevents hardening of the arteries restoring the cells of the arteries even more than calcium aspartate

Dr. Nieper generally combined magnesium orotate with other nutrients for optimal effect. For example, it’s known that potassium deficiency is closely linked with magnesium deficiency. In addition, potassium orotate itself is thought to be beneficial for conditions such as cardiomyopathy and congestive heart failure.

Excess Acidity in the Heart Muscle as a Preparation for Cardiac Infarction
In preparation for cardiac infarction, initially the heart muscle’s acidity increases strongly, i.e., its pH decreases.

The physiology professor, Schmidt-Schön­bein, from Aachen, Germany showed that during excessive blood acidity, the red blood corpuscles become rigid and are no longer plastic (pliable) enough. Normally, a red blood corpuscle can become so thin that it readily passes through an opening much smaller than its normal diameter. However, when the red blood corpuscles become rigid due to excessive blood acidity, then they can clog the end network of fine capillary branches. They then cause renewed damage. For this reason, acidification of the blood in the heart muscle must absolutely be avoided.

When potassium magnesium aspartate, magnesium orotate and carnitine are supplied the pH becomes alkaline again. The intracellular delivery of these nutrients stimulates the production of ATP, accelerating glucose entry into and acid flow out of the cell causing the danger of heart muscle necrosis or cardiac infarction to recede.

Improving Blood Vessel Elasticity while Lowering Blood Pressure
The magnesium from the specifically-transported magnesium orotate activates enzymes which then “clean” the organism of deposits, for example, of cholesterol layers in the vessels. In addition to its cholesterol-lowering and heart-energizing effects; magnesium orotate has been reported to improve the elasticity of blood vessels. Using capillarographic recordings Dr. Nieper was able to show that a daily dose of 380 mg magnesium orotate over 15 months was sufficient to normalize or greatly improve the elasticity of peripheral blood vessels in 60 of 64 patients. Such an effect on vessel elasticity suggests the use of magnesium orotate for lowering blood pressure as well as for inhibiting arteriosclerosis.

Unclogging Arteries and Inhibiting Arteriosclerosis
A Nieper combination designed for unclogging arteries involved magnesium orotate, together with carnitine, selenium and bromelain. This combination of nutrients produced an excellent cleansing effect on arterial deposits inhibiting platelet aggregation and dissolving fibrin clots. The 2- and 4-year mortality rates for patients on this regimen were reportedly reduced by 90% or more compared to patients in other studies who received conventional medications.

Improving the Heart’s Pacemaker Function
Dr. Nieper’s research indicated that ionic detergent residues (especially those used in dish washers) impair the combustion process of neutral fats. He said, “They also exert their damaging influence on the pentose-pathway tissue. This can be seen, for instance, in an acute hearing loss, as well as in an abrupt disturbance of the heart’s pacemaker system. It is thus not unusual for an acute hearing loss to be the harbinger of a disturbance of failure in the natural pacemaker system. These deleterious effects to the pacemaker system are fairly easy to overcome if the substrates, which are necessary for the cell’s proper functioning, are supplied. These are vitamin C, potassium orotate, magnesium orotate, calcium orotate, chromium and especially selenium. The orotates mentioned are important because the carrier molecule, orotic acid, has an unusual ability to penetrate into the pacemaker system’s cells. Aspartates (aspartic acid) do not have this ability.”

The Lysosomal Connection
Magnesium orotate is effective in quelling the activity of lysosomal enzymes. During intense acidity levels in the heart muscle, certain enzymes are activated, namely, the lysosomal enzymes. These results in enzymatic destruction of the heart muscle and blood vessel tissue called a “lysosomal chain reaction”.

Dr. Nieper sternly points out: “One substantial injurious factor that leads to an increase in lysosomal frequency in the heart muscle is the smoking of cigarettes. Thus, the consumption of cigarettes leads to countless latent bombs, which can explode at any time, in the context of a chain reaction in the heart muscle. It is thus quite understandable that the increase in cardiac infarction frequency is particularly noted in the case of smokers, while they are not particularly susceptible to a greater degree of coronary sclerosis, in comparison to nonsmokers.” It’s especially important that these people do as much as possible to counteract the tremendously detrimental effects of their insidious addiction. Cigarettes are a legal drug of choice with terrible consequences that seem to have no impact on those addicted who will even ignore the obviously fact that they are committing suicide and at the same time, through second hand smoke, murdering others.

An Important Adjunct to Magnesium Orotate NutriTherapy
TAURINE: The neuroprotective effects of taking taurine for about six months include the significant reductions of ventricular fibrillation. Taurine provides significant cardio-protection against the deleterious effect of free radicals. In a 2004 study by the Hanna et al, the authors conclude that taurine acts as a potent, but non-specific, scavenger of free radicals that cause heart damage and protects against reperfusion-induced ventricular.

In Japan, taurine therapy us used in the treatment of ischemic heart disease with supplements of 5-6 grams daily in three divided doses. Low taurine and magnesium levels were found in patients after heart attacks or heart surgery. Taurine also treats arrhythmias, especially arrhythmias secondary to ischemia. People with congestive heart failure have also responded to a dosage of 2 grams three times daily with improved cardiac and respiratory function. Other cardiovascular uses of taurine include hypertension, especially those related to effects in rennin-angiotensin system of the kidneys, and in patients with high cholesterol levels.

Healthy Athletes Benefit from Magnesium Orotate
Finally, it’s worth pointing out that magnesium orotate isn’t just for heart patients-it’s also for healthy athletes. In a double-blind, randomized study competitive triathletes had greater endurance as a result of the magnesium orotate supplements. By contrast, a different study in which athletes were supplemented with magnesium oxide (which is relatively poorly absorbed) reported no improvement in exercise performance, attesting to the superior uptake of magnesium in the orotate form compared to the oxide.

Ed Sharpe reports: With regard to the other orotates, I have previously mentioned that magnesium orotate increases endurance in exercising athletes and that potassium orotate has been shown to increase blood levels of reduced glutathione, the body’s natural antioxidant. Since endurance depends critically on the levels of oxidative stress in exercising muscle, I guessed that adding some potassium orotate to the magnesium orotate I was already taking might yield even better results. In general I take one tablet of each of the orotates every morning; on exercise days, I increase the dose by taking an extra tablet each of potassium and magnesium orotate an hour or two before heading for the gym. It didn’t take long for the results to become obvious. I’m now pushing heavier weights on the Nautilus machine than I’ve ever done previously.

Magnesium Orotate and Cancer
“We have had a large number of patients under long-term magnesium orotate therapy because of angina pectoris and other cardiac metabolism disturbances. This treatment has such a positive effect that the patients themselves request renewed prescriptions once they run out of tablets. Thus, long-term therapy necessarily results” reports Nieper.

“For some time we have observed, with some surprise, that hardly any new cancer occurrences appear in this group of patients. The probability for this is so small, in fact, that in cases of doubt and for acute complaints, a diagnosis of cancer is highly unlikely. The rate of new cancerous diseases with long-term magnesium orotate therapy is perhaps less than 20% of the frequency otherwise expected, at least for the first 10 years of the observation period.” Dr. Nieper quips, “Use of magnesium orotate would be a nightmare for any government if it should turn out to be true that this substance is as effective in cancer prevention as it is in the prevention of cardiac and circulatory diseases, this would severely threaten the collapse of all retirement-financing plans.

Nieper states: “Today we know that cancer of the cervix is caused – or better yet “started” – by a virus of the herpes family. The start of cervical cancer can be of a fairly aggressive nature and is characterized by one peculiarity: the bodies own immunological defense systems, especially those of the lymphocytes and of steroid surveillance, are quite ineffective against this cancer from the very beginning, in contrast to many other tumors.”

He than warns us: “In this context, another peculiarity exists: the administration of sodium fluoride in drinking water and, probably to the same extent, in tablets (also for children) clearly increases the rate of cancer incidence. “On the other hand, there is a peculiarity in connection with the occurrence of cervical cancer, which has directly affected my work recently. This is the shortage of a certain complement (C3c) which is a component of blood albumen, having a complex structure, and which must be coupled to antibodies or defensive cells to render their action against viruses effective. This finding allows the conclusion that the shortage of such a complement is responsible for the fact that herpes virus can start its malignant activity on the skin cells of the cervix. Incidentally, a complement deficiency can be eased by supplying magnesium orotate and zinc aspartate, as well as selenium and molybdenum (from cauliflower), and Squalene.”

Meanwhile the strong suspicion has arisen that in many other organ tumors, viruses – especially of the herpes group, as well as those of hepatitis-B and the so-called cytomegalovirus– are more or less co-responsible for the initiation of the malignant process, i.e., for the real cancer genesis in the cell. This suspicion applies to the following tumors: ovaries; bladder; kidneys; prostate; all tumors in the nose, mouth and throat area; certain tumors of the so-called adenocarcinoma type, of the windpipe and the bronchia in the lungs; lymphomas; the so-called clear cell melanomas; melanomas in general; and pancreas, which was repeatedly observed following acute shingles.

It also applies to primary liver cancer after earlier viral hepatitis-B. Furthermore, apparently viruses of the herpes group also play a role in Hodgkin’s Disease. However, the latter must be included among the immune diseases, which can also lead to – among other things – the development of equally malignant primary tumors at several locations. Finally, there are several originally tropical tumors, such as the so-called Burkitt lymphoma, caused by Epstein-Barr viruses, which belong to the herpes group.

Thus the role of a virus in cancer, at least as a causative factor, is apparently much more important than previously imagined.

Insomnia and Fatigue Fighter
Dr. Nieper found Magnesium Orotate especially effective against insomnia, fatigue. He reports: “One of my private patients who had severe insomnia for 42 years, just responded to magnesium orotate in a miraculous way.”

PubMed Studies:I found hundreds of research articles regarding the effectiveness of Magnesium Orotate. In study after study MgOr has proven to be cardio protective. These studies indicate that magnesium orotate is myocardial and neuronal protective too. MgOr is indicated for the treatment of Mg depletion and also in coronary heart patients undergoing e.g. aortocoronary bypass surgery. Here are just a couple of examples.

Metabolic supplementation with orotic acid and magnesium orotate.

Orotic acid (OA), a naturally occurring substance, is a key intermediate in the biosynthetic pathway of pyrimidines. Previous investigations in the heart suggest that orotate can protect recently infarcted hearts against a further ischemic stress and may be beneficial in certain types of experimental cardiomyopathy. At the Hamburg symposium on magnesium orotate, a number of studies of this form of metabolic supplementation were presented that indicate orotic acid and its magnesium salt have a modest beneficial effect on the myocardium under conditions of stress ranging from myocardial infarction to severe physical exercise. The following conclusions can be drawn: (1) Orotic acid can improve the energy status of the recently infarcted myocardium (rat hearts). (2) Orotic acid may improve myocardial purine and pyrimidine levels by stimulating hepatic release of uridine into the bloodstream, which in turn augments depleted myocardial pyrimidines and purines (rat heart). (3) Orotic acid improves the tolerance of the recently infarcted heart to global ischemia (rats). (4) Magnesium orotate may reduce the severity of chronic myocardial dysfunction and structural damage in cardiomyopathy (cardiomyopathic hamsters). (5) Magnesium orotate may improve exercise tolerance in patients with coronary artery disease and in trained athletes (humans). (6) Magnesium orotate has only a weak inotropic effect, if any, on normal hearts (rats). (7) Further clinical testing is indicated to determine if the effects described could be of significant clinical benefit in the treatment of heart disease.

Magnesium orotate in myocardial and neuronal protection.

Rom J Intern Med. 1999 Jan-Mar;37(1):91-7. Zeana C.

Department of Internal Medicine, Floreasca Emergency Hospital 8, Calea Floreasca, 71406 Bucharest, Romania.

Magnesium orotate molecule includes two synergic protective components: orotic acid and magnesium. Moreover, the orotic acid behaves as a transporter, carrying magnesium into the cells. The antioxidative protective effect of the orotic acid is mainly due to the pirimidinic bases that favor and increased synthesis of enzymes which act as free radical scavengers. The cell antioxidative protective system is dramatically impaired following heavy aggressions such as the ischemia. Magnesium orotate improves the survival of cells situated within the perinecrotic areas as well as of the cells secondarily damaged during the so-called “second wind”.

DNA REPROGRAMMING
This is a comprehensive biomedical protocol to assist in restoring damaged DNA to its previous, normal state. To learn more read the article “Speaking the Language that Reprograms the DNA”.

1. DNA Reprogramming can be used to clear heart muscle acidity, blood acidity and lysosomal enzymes.
2. Check and if needed use DNA Reprogramming for defective Complement (C3c).
3. DNA Reprogramming can be used to clear the Herpes virus family, including cytomegalovirus and Epstein Barr. This often requires more than one clearing due to the insidious nature of and the many strains in the Herpes Family
4. In light of Dr. Nieper’s observation that Liver Cancer is often associated with Hepatitis B DNA Reprogramming can be used to check for and clear this virus if needed

NUTRITHERAPY RECIPES FOR HEALTH

1. For Treating Angina and Coronary Heart Disease. Magnesium orotate plus Potassium orotate.
2. Moving the pH from Acid to Alkaline: Potassium magnesium aspartate, Magnesium orotate, and Carnitine are supplied 2-3 times/day
3. Unclogging arteries: Take magnesium orotate, together with carnitine, selenium and bromelain.
4. Improving Pacemaker Function by taking Vitamin C, potassium orotate, magnesium orotate, calcium orotate, and Vanachrom.
5. Lysosomal Enzyme dysfunction and Free Radicals: Mg-orotate and K-Mg-Aspartate, Bromelain and Taurine
6. Restoring Complement C3c: A complement deficiency can be eased by supplying magnesium orotate and zinc aspartate, as well as selenium and molybdenum, and Squalene.

IMPORTANCE NOTICE: The information disseminated herein, whether in print or through the internet, is not intended to replace the attention or advice of a physician or other health care professional. Anyone who wishes to embark on any dietary, drug, exercise, or other lifestyle change intended to prevent or treat a specific disease of condition should first consult directly with and seek clearance from a qualified health care professional.